Résumé : Publiée dans le cadre du premier Congrès international d'histoire coloniale à Paris
Siècle(s) traité(s) : 20
Droits : Domaine public
Provenance : Ville de Pointe-à-Pitre. Réseau des bibliothèques
Permalien : http://www.manioc.org/patrimon/PAP11103
PAP11103

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Geological Society
Résumé : International audience
We constrain the slip and cooling history of the Mykonos detachment footwall using thermochronometry. A U-Pb zircon age of 13.5 +/- 0.3 Ma dates intrusion of the Mykonos monzogranite. Ar-40/ Ar-39 homblende and biotite ages from the monzogranite are 12.7 +/- 0.6 Ma and 10.9 +/- 0.6 Ma, whereas zircon and apatite fission-track ages range from 13 +/- 0.8 Ma to 10.7 +/- 0.8 Ma and 12.5 +/- 2.2 Ma to 10.5 +/- 1.8 Ma. (U-Th)/He ages range from 13.6 +/- 0.6 Ma to 9.0 +/- 0.7 Ma for zircon and 11. +/- 10.5 Ma to 8.9 +/- 0.4 Ma for apatite. The ages in part overlap within 2 sigma errors and together with the long apatite fission-track lengths (>14 mu m) support rapid cooling at rates > 100 degrees C Ma(-1). The low-temperature thermochronometric ages decrease east-northeastwards in the direction of hanging-wall transport on the Mykonos detachment. Age-distance relationships show that the Mykonos detachment slipped at an average rate of 6.0 + 9.2/-2.4 km Ma(-1) c. 30 km of offset and c. 12 km of exhumation. This result indicates that Miocene low-angle normal faulting was not important for the exhumation of the Cycladic blueschist unit. The opening of the Aegean Sea basin in the Miocene was controlled by a few large-magnitude low-angle normal faults.
ISSN: 0016-7649

hal-00412177
https://hal.archives-ouvertes.fr/hal-00412177
DOI : 10.1144/0016-76492006-145

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND: Africa faces a number of unique environmental challenges. Unfortunately, it lacks the infrastructure needed to support the comprehensive environmental studies that could provide the scientific basis to inform environmental policies. There are a number of known sources of endocrine-disrupting chemicals (EDCs) and other hazardous chemicals in Africa. However, a coordinated approach to identify and monitor these contaminants and to develop strategies for public health interventions has not yet been made. OBJECTIVES: This commentary summarizes the scientific evidence presented by experts at the First African Endocrine Disruptors meeting. We describe a "call to action" to utilize the available scientific knowledge to address the impact of EDCs on human and wildlife health in Africa. DISCUSSION: We identify existing knowledge gaps about exposures to EDCs in Africa and describe how well-designed research strategies are needed to address these gaps. A lack of resources for research and a lag in policy implementation slows down intervention strategies and poses a challenge to advancing future health in Africa. CONCLUSION: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774.
Environmental Health Perspectives

hal-01616487
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616487
DOI : 10.1289/EHP1774
PUBMED : 28935616

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : Zircon and apatite fission track (ZFT and AFT) and (U-Th)/He, ;40;Ar/;39;Ar hornblende, and U-Pb zircon ages from the granites of Tinos Island in the Aegean Sea, Greece, suggest, together with published ZFT data, that there are three extensional detachments on Tinos. The Tinos granites crosscut the Tinos detachment. Cooling of the granites was controlled by the Livadi detachment, which occurs structurally above the Tinos detachment. Our U-Pb zircon age is 14.6 ± 0.2 Ma and two ;40;Ar/;39;Ar hornblende ages are 14.4 ± 0.4 and 13.7 ± 0.4 Ma. ZFT and AFT ages go from 14.4 ± 1.2 to 12.2 ± 1.0 Ma and 12.8 ± 2.4 to 11.9 ± 2.0 Ma. (U-Th)/He ages are from 10.4 ± 0.2 to 9.9 ± 0.2 Ma (zircon) and 11.9 ± 0.5 to 10.0 ± 0.3 Ma (apatite). All ages decrease northeastward in the direction of hanging wall transport on the Livadi detachment and age-distance relationships yield a slip rate of 2.6 (+3.3 / −1.0) km Ma;−1;. This rate is smaller than a published slip rate of 6.5 km Ma;−1; for the Vari detachment, which is another detachment structurally above the Tinos detachment. Because of the different rates and because published ZFT ages from the footwall of the Vari detachment are ∼10 Ma, we propose that the Vari detachment has to be distinguished from the older Livadi detachment. We discuss various models of how the extensional detachments may have evolved and prefer a scenario in which the Vari detachment cut down into the footwall of the Livadi detachment successively exhuming deeper structural units. The thermochronologic ages demonstrate the importance of quantitative data for constraining localization processes during extensional deformation.
ISSN: 0278-7407

hal-00407638
https://hal.archives-ouvertes.fr/hal-00407638
DOI : 10.1029/2006TC001969

Éditeur(s) : London : printed for the author
Résumé : "Epigraphe au verso du titre : "Qui maris atque telluris stupendas metamorphoses contemplari cupit, vix ullibi terrarum reperiet commodiorem occasionem" Lin. Orat. Edition originale - Dédicace au prince de Galles. - Liste des souscripteurs. - Index. - Bandeaux et culs-de-lampe gravés sur bois - 49 planches gravées sur cuivre (38 pour la flore et 11 pour la faune) d'après G.D. Ehret et F. Garden. - Manquent les 2 cartes dépliantes de la Jamaïque. - Demi-reliure papier peigné, fin 18e-début 19e siècle. - Quelques annotations manuscrites au crayon, écriture du 19e siècle. Un feuillet volant annoté inséré entre les p. 222 et 223. - Plante séchée insérée entre les p. 350 et 351. - Cachet de la bibliothèque de la Ville de Bordeaux Brunet, I, 1282. - Chalmers, The General Biographical Dictionary, VII, p. 134. - Sabin, 8670"
Siècle(s) traité(s) : 18
Droits : Domaine public
Provenance : Ville de Bordeaux. Bibliothèque municipale
Permalien : http://www.manioc.org/patrimon/BBX17028
BBX17028